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calabrese library  (Addgene inc)


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    Addgene inc calabrese library
    Calabrese Library, supplied by Addgene inc, used in various techniques. Bioz Stars score: 93/100, based on 28 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/calabrese library/product/Addgene inc
    Average 93 stars, based on 28 article reviews
    calabrese library - by Bioz Stars, 2026-04
    93/100 stars

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    A) Overview of CRISPR screen methodology (adapted from ). B) SW620 KO screen;-log 10 RRA scores in cells treated with 0.38µM ( left ) or 0.5µM OxPt ( right ) at Day 20 compared to control untreated cells at Day 20. C) RKO KO screen;-log 10 RRA scores in cells treated with 1.9µM OxPt at Day 20 compared to control untreated cells at Day 20. D) SW620 CRISPRa screen;-log 10 RRA scores in cells treated with 0.38µM ( left ) or 0.5µM OxPt ( right ) at Day 20 compared to control untreated cells at Day 20. E) RKO CRISPRa screen;-log 10 RRA scores in cells treated with 1.9µM at Day 20 compared to control untreated cells at Day 20. In each graph, top 5 hits are labeled; significant hits are colored (blue or lilac) while non-significant hits are in grey.

    Journal: bioRxiv

    Article Title: A whole genomic CRISPR-Cas9 screen identifies the amino acid transporter SLC43A1 (LAT3) as a major determinant of oxaliplatin sensitivity in colorectal cancer cells

    doi: 10.1101/2025.04.21.649594

    Figure Lengend Snippet: A) Overview of CRISPR screen methodology (adapted from ). B) SW620 KO screen;-log 10 RRA scores in cells treated with 0.38µM ( left ) or 0.5µM OxPt ( right ) at Day 20 compared to control untreated cells at Day 20. C) RKO KO screen;-log 10 RRA scores in cells treated with 1.9µM OxPt at Day 20 compared to control untreated cells at Day 20. D) SW620 CRISPRa screen;-log 10 RRA scores in cells treated with 0.38µM ( left ) or 0.5µM OxPt ( right ) at Day 20 compared to control untreated cells at Day 20. E) RKO CRISPRa screen;-log 10 RRA scores in cells treated with 1.9µM at Day 20 compared to control untreated cells at Day 20. In each graph, top 5 hits are labeled; significant hits are colored (blue or lilac) while non-significant hits are in grey.

    Article Snippet: The Human Calabrese CRISPR Activation Pooled Library Set A was a gift from David Root and John Doench (Addgene viral prep #92379-LVC) ( ).

    Techniques: CRISPR, Control, Labeling